دکتر سید سهراب هاشمی فشارکی
سه شنبه, ۱ خرداد ۱۳۹۷، ۰۴:۴۹ ق.ظ
دکتر سیدسهراب هاشمی فشارکی
استان تهران، شهر تهران، میدان هفتم تیر، خیابان قائم مقام فراهانی، کوچة سام، پلاک 13، زنگ 4
دکتر سهراب هاشمی فشارکی فارغ التحصیل رشتة پزشکی از دانشگاه اصفهان بوده و دورة «مغزواعصاب» را در دانشگاه تهران طی‌کرده است. وی به تازگی با راه اندازی واحد EMU (اپی پسی. مانتیورینگ – یونیت) به پایش و کنترل روند درمان بیماران می‌پردازد.
دکتر سید سهراب هاشمی فشارکی
فرزند حاج سید زین العابدین هاشمی فشارکی نوه سید حیدرهاشمی فشارکی استادیار گروه مغز واعصاب دانشگاه علوم پزشگی امیر المومنین (ارتش)
استادیار گروه نورولوژی دانشگاه علوم پزشگی بقیه الله نشانی-تهران -خ شهید مطهری-خ فجر -بیمارستان جم تهران -بلوار کشاورز-بیمارستان ساسان
مسئولیت ها: ریاست کلینیک تشنج مرکز علوم اعصاب بیمارستان خاتم النبیاء-پژوهشکده مهندسی وعلوم پزشکی جانبازان
عضوشورای علمی مرکز علوم اعصاب بیمارستان خاتم الانبیا پژوهشکده مهندسی وعلوم پزشکی جانبازان
Seyed Sohrab Hashemi Fesharaki's research while affiliated with Shefa Neuroscience Research Center and other places
Ictal asystole is a rare, probably underestimated manifestation of epileptic seizures whose pathophysiology is still debated. This report describes two patients who had cardiac asystole at the end of their seizure. The first patient was a 13-year-old boy with complex partial seizures.. His MRI showed symmetrical signal abnormality in the bilateral parietooccipital lobe accompanied by mild gliosis and volume loss. During a 3-day long-term video-EEG monitoring, he had cardiac arrest at the end of one of his seizures that was secondarily generalized. The second one was a 42-year-old veteran with penetrating head trauma in the left frontal lobe due to shell injury. During long-term video-EEG monitoring, he had one generalized tonic–clonic seizure accompanied by bradycardia and cardiac asystole. Asystoles could have a role in the incidence of sudden unexpected death in epilepsy (SUDEP), meaning that the presence of ictal bradycardia is a risk factor for SUDEP. In cases of epileptic cardiac dysrhythmia, prolonged simultaneous EEG/ECG monitoring may be required. Cardiological investigation should be included in epilepsy management.
Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at efficacy of bumetanide, a specific NKCC1 antagonist, on reduction of seizure frequency in adult patients with temporal lobe epilepsy. According to our results, seizure frequency was reduced considerably in these patients. Furthermore, epileptiform discharges decreased in two of our patients. If the efficacy of bumetanide is proven in large scale studies, it can be used as a supplemental therapy in temporal lobe epilepsy.
Epilepsy is a common, chronic neurological disorder that affects more than 40 million people worldwide. Epilepsy is characterized by interictal and ictal functional disturbances. The presence of interictal epileptiform discharges (IEDs) can help to confirm a clinical diagnosis of epilepsy, and their location and characteristics can help to identify the epileptogenic zone or suggest a particular epilepsy syndrome. The aim of this study is to determine the factors that affect IEDs. Poisson marginal model was done on 60 epileptic patients who were referred to Shefa Neurological Research Center, Tehran, for Video-Electroencephalogram (V-EEG) monitoring from 2007 to 2011. The frequency of IEDs was assessed by visual analysis of interictal EEG samples for 2 h. The results show that among age, epilepsy duration, gender, seizure frequency and two common anti-epileptic drugs (Valproic acid and Carbamazepine), only age and epilepsy duration had statistical significant effect on IED frequency. Investigating the factors affecting IED is not only of theoretical importance, but may also have clinical relevance as understanding the evolution of interictal epileptogenesis may lead to the development of therapeutic interventions. Generalized estimating equation is a valid statistical technique for studying factors that affect on IED. This research demonstrates epilepsy duration has positive and age has negative effect on IED which means that IED increases with epilepsy duration and decreases with increasing age. So for monitoring IED, we should consider both age and epilepsy duration of each patient.
Gastrointestinal (GI) discomforts are among the most common side effects of antiepileptic drugs (AEDs) that might lead to discontinuation or irregular consumption of the drugs. This study was conducted to evaluate the frequency of GI side effects of different AEDs in intractable epileptic patients treated with single or multiple drugs. GI discomfort of 100 epileptic patients (aged 35-76 years) treated with one or multiple AEDs was assessed. Seventy six patients (76%) were treated with two or more AEDs, and 24 (24%) were on monotherapy. The most common prescribed drug for monotherapy was carbamazepine and the most frequent combination was phenytoin and carbamazepine. Patients were suffering from different GI side effects including heartburn (34.6%), nausea (33.7%), constipation (26%), vomiting (22.1%), diarrhea (21.2%) and dysphagia (19.2%). Nausea and vomiting were significantly higher in patients receiving monotherapy with carbamazepine and valproic acid, respectively. When phenytoin, gabapentine, or valproic acid was added to the other AEDs, the risk of the occurrence of diarrhea, dysphagia, or heartburn was significantly increased, respectively. Addition of gabapentine to the other AEDs in multiple drug therapy was accompanied with the highest frequency of GI complications. This study indicated that GI side effects, which can affect drug absorption and utilization, were common in intractable epileptic patients with long-term AEDs treatment. This may influence the efficacy of the therapy with AEDs and enhance the probability of further attacks.
... Up-regulation of NKCC1 is reported in ganglioglioma, a tumour almost always associated with seizures, and coincides with downregulation of KCC2 [29,33]. Moreover, treatment with bumetanide, an NKCC1 antagonist, reduces seizure frequency in patients with temporal lobe epilepsy [34]. Taken together, these data suggest NKCC1 as a potential therapeutic target for TRE, and warrants further investigation of its role in TRE [35]. ...
... Fatemeh Fadaie et al. reported that the momentary cardiac arrest was observed during seizure, which indicated that the patients with epilepsy were at risk of sudden death. Therefore, it will benefit the patient with epilepsy if cardiac monitoring could be conducted as part of daily management[20]. Although there were many studies regarding the relation between HRV and adult with epilepsy[24], the relation between the HRV and the children with epilepsy has been seldom explored. ...
http://biography.powerset.ir/بیوگرافی-دکتر-سهراب-هاشمی-فشارکی
https://medicine.yale.edu/people/organizations/arman_fesharaki.profile
https://www.researchgate.net/scientific-contributions/56995291_Seyed_Sohrab_Hashemi_Fesharaki
http://javadfesharaki.blog.ir/1397/03/01/دکتر%20سید%20سهراب%20هاشمی%20فشارکی
