DEXTROMETHORPHAN REDUCES POSTOPERATIVE PAIN OF POST PARTUM TUBAL LIGATION UNDER GENERAL ANESTHESIA

 HASHEMI FESHARAKI S.M.

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   SPRING 2009 , Volume 16 , Number 1 ((SN 51); Page(s) 23 To 27.

Paper:  DEXTROMETHORPHAN REDUCES POSTOPERATIVE PAIN OF POST PARTUM TUBAL LIGATION UNDER GENERAL ANESTHESIA

Author(s):  MANOUCHEHRIAN N.*, HASHEMI FESHARAKI S.M., HAJIAN P., KHOUSHRAFTAR E.

* DEPARTMENT OF ANESTHESIOLOGY, SCHOOL OF MEDICINE, HAMADAN UNIVERSITY OF MEDICAL SCIENCES & HEALTH SERVICES, HAMADAN, IRAN

Abstract: 

Introduction & Objective: Postoperative pain has harmful effects in many systems. Dextromethorphan reduces postoperative pain in post partum tubal ligation under general anesthesia.
Materials & Methods: In this research 40 patients with ASA class I and II in double blind randomized clinical trial were studied in two groups. 90 minutes before surgery the patients received 90 mg dextromethorphan or placebo (oral). The patients induced general anesthesia with thiopental (5mg/kg), fentanyl 1.5 mg/kg and succinylcholin(1-1.5 mg/kg) and maintenance with halothane and N₂O 50%. Patients were observed studied for analgesic requirement, nausea, vomiting, urinary retention and respiratory depression in recovery and 2, 4, 8 and 24 hours after surgery.
Results: There was no significant difference in age, education, . . . Pain in recovery, 2 and 4 hours after surgery in dextromethorphan was less than placebo group. The analgesic requirement (pethidine) in dextromethophan was less than placebo group.
Conclusion: Administration of 90 mg dextromethorphan 90 minutes before the surgery under GA reduces pain in recovery time , 2 and 4 hours after the surgery.

Keyword(s): PAIN, DEXTROMETHORPHAN, STERILIZATION, TUBAL

 

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